Modes of Vesicle Retrieval at Ribbon Synapses, Calyx-Type Synapses, and Small Central Synapses
نویسندگان
چکیده
منابع مشابه
Modes of vesicle retrieval at ribbon synapses, calyx-type synapses, and small central synapses.
Introduction Endocytosis is essential for the maintenance of synaptic transmission because it recycles and thus prevents complete depletion of synaptic vesicles in the nerve terminal. The goal of understanding synaptic vesicle recycling mechanisms was launched in earnest in 1973 when John Heuser and Tom Reese published their landmark electron microscope images of synaptic terminals of the frog ...
متن کاملRibbon synapses
Why are these synapses special? Because the electrical signals they transmit are not the same as those in other parts of the brain. Conventional synapses convey information arriving as a ‘pulse code’; action potentials lasting a few milliseconds trigger a transient burst of vesicle fusion and the amplitude of the action potential is fixed. But ribbon synapses transmit ‘analogue signals’, such a...
متن کاملRab3A mediates vesicle delivery at photoreceptor ribbon synapses.
Rab3A is a synaptic vesicle-associated protein found throughout the nervous system, but its precise function is unknown. Genetic knock-out studies show that Rab3A is not necessary for vesicular release or replenishment at conventional synapses in the brain. Here we explore the function of Rab3A at ribbon synapses in the retina of the tiger salamander (Ambystoma tigrinum). Fluorescently labeled ...
متن کاملMunc13-independent vesicle priming at mouse photoreceptor ribbon synapses.
Munc13 proteins are essential regulators of exocytosis. In hippocampal glutamatergic neurons, the genetic deletion of Munc13s results in the complete loss of primed synaptic vesicles (SVs) in direct contact with the presynaptic active zone membrane, and in a total block of neurotransmitter release. Similarly drastic consequences of Munc13 loss are detectable in hippocampal and striatal GABAergi...
متن کاملEpsin1 modulates synaptic vesicle retrieval capacity at CNS synapses
Synaptic vesicle retrieval is an essential process for continuous maintenance of neural information flow after synaptic transmission. Epsin1, originally identified as an EPS15-interacting protein, is a major component of clathrin-mediated endocytosis. However, the role of Epsin1 in synaptic vesicle endocytosis at CNS synapses remains elusive. Here, we showed significantly altered synaptic vesic...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2007
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3471-07.2007